A new species of Cyrtopodium from west-northwest Venezuela and from Departamento de Córdoba in Colombia is described and illustrated. It is related to and in the past was confused with Cyrtopodium punctatum, a species from Florida and the Greater Antilles, from which it is easily distinguished based on its much larger and wider bracts and sepals with slightly wavy margins. It differs from all other Venezuelan species of Cyrtopodium in its epiphytic habit and the presence of aerial roots like the ones observed in species of subtribe Catasetinae. Its large flowers and the different proportions of the floral segments distinguish it from Brazilian epiphytic Cyrtopodium species such as C. gigas and C. palmifrons.